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The actin-based motor protein myosin II regulates MHC class II trafficking and BCR-driven antigen presentation.

Abstract : Antigen (Ag) capture and presentation onto major histocompatibility complex (MHC) class II molecules by B lymphocytes is mediated by their surface Ag receptor (B cell receptor [BCR]). Therefore, the transport of vesicles that carry MHC class II and BCR-Ag complexes must be coordinated for them to converge for processing. In this study, we identify the actin-associated motor protein myosin II as being essential for this process. Myosin II is activated upon BCR engagement and associates with MHC class II-invariant chain complexes. Myosin II inhibition or depletion compromises the convergence and concentration of MHC class II and BCR-Ag complexes into lysosomes devoted to Ag processing. Accordingly, the formation of MHC class II-peptides and subsequent CD4 T cell activation are impaired in cells lacking myosin II activity. Therefore, myosin II emerges as a key motor protein in BCR-driven Ag processing and presentation.
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https://hal.archives-ouvertes.fr/hal-00316389
Contributor : Nadine Loudig Connect in order to contact the contributor
Submitted on : Wednesday, September 3, 2008 - 10:07:09 AM
Last modification on : Thursday, August 4, 2022 - 4:52:49 PM

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Fulvia Vascotto, Danielle Lankar, Gabrielle Faure-André, Pablo Vargas, Jheimmy Diaz, et al.. The actin-based motor protein myosin II regulates MHC class II trafficking and BCR-driven antigen presentation.. Journal of Cell Biology, 2007, 176 (7), pp.1007-19. ⟨10.1083/jcb.200611147⟩. ⟨hal-00316389⟩

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