Out-of-equilibrium microrheology inside living cells

Claire Wilhelm (1)

1 MSC - Matière et Systèmes Complexes

Both forced and spontaneous motions of magnetic microbeads engulfed by Dictyostelium cells have served as experimental probes of intracellular dynamics. The complex shear modulus G∗(ω), determined from active oscillatory measurements, has a power-law dynamics and increases with the probe size, reflecting intracellular structural complexity. The combined use of passive microrheology allows one to derive the power spectrum of active forces acting on intracellular phagosomes and to test the validity of the fluctuation-dissipation theorem inside living cells.

Domaines: Biomécanique [physics.med-ph]

Claire Wilhelm. Out-of-equilibrium microrheology inside living cells. Physical Review Letters, 2008, 101 (2), pp.028101. ⟨10.1103/PhysRevLett.101.028101⟩. ⟨hal-00315471⟩