Geno3D: automatic comparative molecular modelling of protein.

C. Combet (1) , M. Jambon (1) , G. Deleage (1) , C. Geourjon (1)

1 IBCP - Institut de biologie et chimie des protéines [Lyon]

Geno3D (http://geno3d-pbil.ibcp.fr) is an automatic web server for protein molecular modelling. Starting with a query protein sequence, the server performs the homology modelling in six successive steps: (i) identify homologous proteins with known 3D structures by using PSI-BLAST; (ii) provide the user all potential templates through a very convenient user interface for target selection; (iii) perform the alignment of both query and subject sequences; (iv) extract geometrical restraints (dihedral angles and distances) for corresponding atoms between the query and the template; (v) perform the 3D construction of the protein by using a distance geometry approach and (vi) finally send the results by e-mail to the user.Geno3D (http://geno3d-pbil.ibcp.fr) is an automatic web server for protein molecular modelling. Starting with a query protein sequence, the server performs the homology modelling in six successive steps: (i) identify homologous proteins with known 3D structures by using PSI-BLAST; (ii) provide the user all potential templates through a very convenient user interface for target selection; (iii) perform the alignment of both query and subject sequences; (iv) extract geometrical restraints (dihedral angles and distances) for corresponding atoms between the query and the template; (v) perform the 3D construction of the protein by using a distance geometry approach and (vi) finally send the results by e-mail to the user.

Domaines: Biochimie, Biologie Moléculaire

C. Combet, M. Jambon, G. Deleage, C. Geourjon. Geno3D: automatic comparative molecular modelling of protein.. Bioinformatics, 2002, 18, pp.213-214. ⟨hal-00313011⟩