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LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development.

Abstract : In humans, low peak bone mass is a significant risk factor for osteoporosis. We report that LRP5, encoding the low-density lipoprotein receptor-related protein 5, affects bone mass accrual during growth. Mutations in LRP5 cause the autosomal recessive disorder osteoporosis-pseudoglioma syndrome (OPPG). We find that OPPG carriers have reduced bone mass when compared to age- and gender-matched controls. We demonstrate LRP5 expression by osteoblasts in situ and show that LRP5 can transduce Wnt signaling in vitro via the canonical pathway. We further show that a mutant-secreted form of LRP5 can reduce bone thickness in mouse calvarial explant cultures. These data indicate that Wnt-mediated signaling via LRP5 affects bone accrual during growth and is important for the establishment of peak bone mass.
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https://hal.archives-ouvertes.fr/hal-00306959
Contributor : Georges Carle <>
Submitted on : Monday, July 28, 2008 - 4:13:27 PM
Last modification on : Sunday, November 22, 2020 - 6:22:02 PM

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  • HAL Id : hal-00306959, version 1
  • PUBMED : 11719191

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Y. Gong, R. B. Slee, N. Fukai, G. Rawadi, S. Roman-Roman, et al.. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development.. Cell, Elsevier, 2001, 107 (4), pp.513-23. ⟨hal-00306959⟩

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