Cutting edge: Overlapping functions of TLR7 and TLR9 for innate defense against a herpesvirus infection. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Immunology Année : 2008

Cutting edge: Overlapping functions of TLR7 and TLR9 for innate defense against a herpesvirus infection.

Résumé

As initially demonstrated with murine cytomegalovirus (MCMV), plasmacytoid dendritic cells (pDCs) are the major source of IFN-alpha/beta in response to a variety of viruses in vivo. However, contradictory results have been obtained pertaining to the mechanisms promoting IFN-alpha/beta production by pDCs in response to MCMV. In this study we show that TLR7 and TLR9 exert redundant functions for IFN-alpha/beta, IL-12p40, and TNF-alpha production by pDCs in vivo during MCMV infection. In contrast, we confirm that systemic production of IL-12p70 strictly depends on TLR9. The combined loss of TLR7 and TLR9 recapitulates critical features of the phenotype of MyD88-deficient mice, including a dramatic decrease in systemic IFN-alpha/beta levels, an increase in viral load, and increased susceptibility to MCMV-induced mortality. This is the first demonstration of the implication of TLR7 in the recognition of a DNA virus.

Domaines

Immunologie
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Dates et versions

hal-00294063 , version 1 (08-07-2008)

Identifiants

  • HAL Id : hal-00294063 , version 1
  • PUBMED : 18424698

Citer

Nicolas Zucchini, Gilles Bessou, Stephanie Traub, Scott H Robbins, Satoshi Uematsu, et al.. Cutting edge: Overlapping functions of TLR7 and TLR9 for innate defense against a herpesvirus infection.. Journal of Immunology, 2008, 180 (9), pp.5799-803. ⟨hal-00294063⟩

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