Detection of enzymatic activity by PARACEST MRI: a general approach to target a large variety of enzymes

Abstract : We report a new family of molecular imaging probes that offer the possibility of specific PARACEST (paramagnetic chemical exchange saturation transfer) MRI detection of a large variety of enzymatic activities. The probes are based on a lanthanide complex coupled to an enzyme-specific substrate through a self-immolative spacer. Upon enzymatic cleavage of the substrate, the spacer is spontaneously eliminated, thereby resulting in a remarkable change in the PARACEST properties of the Ln3+ chelate. This new type of contrast agent opens up new perspectives in molecular magnetic resonance imaging.
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https://hal.archives-ouvertes.fr/hal-00283242
Contributor : Isabelle Frapart <>
Submitted on : Thursday, May 29, 2008 - 2:51:36 PM
Last modification on : Thursday, May 9, 2019 - 4:02:01 PM

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Thomas Chauvin, Philippe Durand, Michèle Bernier, Hervé Meudal, Bich-Thuy Doan, et al.. Detection of enzymatic activity by PARACEST MRI: a general approach to target a large variety of enzymes. Angewandte Chemie International Edition, Wiley-VCH Verlag, 2008, 47 (23), pp.4370-4372. ⟨10.1002/anie.200800809⟩. ⟨hal-00283242⟩

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