Separation of amino acid enantiomers via chiral derivatization and non chiral column by gas chromatography

Abstract : Two GC-MS methods for the enantioselective separation of the 20 proteinogenic amino acids are compared. Ethyl chloroformate and 2-chloropropanol were used to derivatize amino acid enantiomers. The diastereomers formed were separated on a non-chiral column by capillary gas chromatography. The separation performances were compared to those obtained when using non-chiral derivatization on a chiral column.
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Submitted on : Tuesday, May 27, 2008 - 5:17:53 PM
Last modification on : Friday, April 19, 2019 - 1:52:03 PM

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Marylène Bertrand, Annie Chabin, André Brack, Frances Westall. Separation of amino acid enantiomers via chiral derivatization and non chiral column by gas chromatography. Journal of Chromatography A, Elsevier, 2008, 1180 (1-2), pp.131-137. ⟨10.1016/j.chroma.2007.12.004⟩. ⟨hal-00282553⟩

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