Cdk1, Plks, Auroras, and Neks: the mitotic bodyguards.

Patrick Salaün (1) , Yoann Rannou (1) , Claude Prigent (1)

1 IGDR - Institut de Génétique et Développement de Rennes

The coordination of progression through mitosis is mainly orchestrated by protein phosphorylation insured by several serine/threonine kinases. In this short review we will focus on the four main mitotic kinase families: the cyclin-dependent kinase: Cdks, the polo-like kinases: Plks, the Aurora kinases and the NIMArelated kinases: Nerks.

Domaines: Cancer

Patrick Salaün, Yoann Rannou, Claude Prigent. Cdk1, Plks, Auroras, and Neks: the mitotic bodyguards.. Advances in Experimental Medicine and Biology, 2008, Advances in experimental medicine and biology - Vol 617, 617, pp.41-56. ⟨hal-00277808⟩