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Article Dans Une Revue Bioorganic and Medicinal Chemistry Année : 2008

Synthesis, chekpoint kinase 1 inhibitory properties and in vitro antiproliferative activities of new pyrrolocarbazoles

Résumé

In the course of structure–activity relationship studies on granulatimide analogues, new pyrrolo[3,4-c]carbazoles have been synthesized in which the imidazole heterocycle was replaced by a five-membered ring lactam system or a dimethylcyclopentanedione. Moreover, the synthesis of an original structure in which a sugar moiety is attached to the indole nitrogen and to a six-membered D ring via an oxygen is reported. The inhibitory activities of the newly synthesized compounds toward checkpoint kinase 1 and their in vitro antiproliferative activities toward three tumor cell lines: murine leukemia L1210, and human colon carcinoma HT29 and HCT116 are described
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Dates et versions

hal-00277522 , version 1 (06-05-2008)

Identifiants

  • HAL Id : hal-00277522 , version 1

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Elisabeth Conchon, Fabrice Anizon, Bettina Aboab, Roy Golsteyn, Stéphane Leonce, et al.. Synthesis, chekpoint kinase 1 inhibitory properties and in vitro antiproliferative activities of new pyrrolocarbazoles. Bioorganic and Medicinal Chemistry, 2008, 16, pp.4419-4430. ⟨hal-00277522⟩
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