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Article Dans Une Revue Comptes Rendus. Chimie Année : 2008

Liquid crystalline properties of type I collagen: Perspectives in tissue morphogenesis

Résumé

Collagen molecules form the major part of tissues like bone, cornea or tendon where they organize into ordered fibrillar networks. The acid-soluble protein spontaneously assembles in liquid crystalline phases, characterized in polarized light microscopy and X-ray diffraction. Collagen fibrillogenesis obtained in condensed media establishes a link between the fibrillar networks described in vivo and the mesomorphic states obtained in vitro. Cellematrix interactions on these biomimetic materials are currently analysed with perspectives in tissue engineering. In a morphogenetic context, we propose the hypothesis of a liquid crystalline order, between soluble precursor molecules, preceding fibrillogenesis.

Dates et versions

hal-00277299 , version 1 (06-05-2008)

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Marie-Madeleine Giraud-Guille, Emmanuel Belamie, Gervaise Mosser, Frédéric Gobeaux, Sylvain Vigier. Liquid crystalline properties of type I collagen: Perspectives in tissue morphogenesis. Comptes Rendus. Chimie, 2008, 11, pp.245-252. ⟨10.1016/j.crci.2007.05.005⟩. ⟨hal-00277299⟩
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