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Article Dans Une Revue European Journal of Medicinal Chemistry Année : 2008

Synthesis and antiproliferative activities of isoindigo and azaisoindigo derivatives

Résumé

In the course of structure–activity relationship studies, diversely substituted 1-(β- d-acetylatedglucopyranosyl)isoindigo derivatives were prepared from indolines. New 7′-azaisoindigo analogues were also synthesized by coupling a glycosylated isatine and a 7-azaindolin-2-one derivative. Compounds containing a 7′-azaisoindigo framework have never been described before. To get an insight into the substitution pattern required for the best biological potencies, their antiproliferative activities were evaluated toward a human buccal carcinoma cell line (KB) and two human myeloid leukaemia cell lines (K562, HL60)

Domaines

Chimie organique
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Dates et versions

hal-00270595 , version 1 (07-04-2008)

Identifiants

  • HAL Id : hal-00270595 , version 1

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Fadoua Bouchikhi, Fabrice Anizon, Pascale Moreau. Synthesis and antiproliferative activities of isoindigo and azaisoindigo derivatives. European Journal of Medicinal Chemistry, 2008, 43, pp.755-762. ⟨hal-00270595⟩
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