The importance of metal geometry in the recognition of G-quadruplex-DNA by metal-terpyridine complexes.

Abstract : A family of terpyridine metallo-organic complexes has been designed and its recognition properties of G-quadruplex-DNA investigated. The series combines easy synthetic access and good affinity-selectivity ratio for quadruplex-DNA. Our study also highlights that the geometry of the metal center strongly governs the ability of the compounds to discriminate quadruplex from duplex-DNA.
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Journal articles
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https://hal.archives-ouvertes.fr/hal-00259076
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Submitted on : Tuesday, February 26, 2008 - 3:58:11 PM
Last modification on : Wednesday, December 11, 2019 - 10:22:03 AM

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  • HAL Id : hal-00259076, version 1
  • PUBMED : 18019527

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Hélène Bertrand, David Monchaud, Anne de Cian, Régis Guillot, Jean-Louis Mergny, et al.. The importance of metal geometry in the recognition of G-quadruplex-DNA by metal-terpyridine complexes.. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2007, 5 (16), pp.2555-9. ⟨hal-00259076⟩

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