ISG20, an actor of the innate immune response.

Genevieve Degols (1) , Patrick Eldin (1) , Nadir Mechti (1)

1 IRIM - Institut de Recherche en Infectiologie de Montpellier

The interferon (IFN) system is a major effector of the innate immunity that allows time for the subsequent establishment of an adaptive immune response against wide-range pathogens. The effectiveness of IFN to control initial infection requires the cooperation between several pathways induced in the target cells. Recent studies that highlight the implication of the 3'-5' exonuclease ISG20 (IFN Stimulated Gene product of 20 kDa) in the host's defenses against pathogens are summarised in this review.

Domaines: Biologie cellulaire

Genevieve Degols, Patrick Eldin, Nadir Mechti. ISG20, an actor of the innate immune response.. Biochimie, 2007, 89 (6-7), pp.831-5. ⟨10.1016/j.biochi.2007.03.006⟩. ⟨hal-00257627⟩