Registration-based Approach for Reconstruction of High Resolution In Utero Fetal MR Brain Images

François Rousseau (1) , Orit Glenn (2) , Bistra Iordanova (2) , Claudia Rodriguez-Carranza (2) , Dan Vigneron (2) , Jim Barkovich (2) , Colin Studholme (2)

1 LSIIT - Laboratoire des Sciences de l'Image, de l'Informatique et de la Télédétection
2 UCSF - University of California, San Francisco

This paper describes a novel approach to forming high resolution MR images of the human fetal brain. It addresses the key problem of fetal motion by proposing a registration refined compounding of multiple sets of orthogonal fast 2D MRI slices, that are currently acquired for clinical studies, into a single high resolution MRI volume. A robust multi-resolution slice alignment is applied iteratively to the data to correct motion of the fetus that occurs between 2D acquisitions. This is combined with an intensity correction step and a super resolution reconstruction step, to form a single high isotropic resolution volume of the fetal brain. Experimental validation on synthetic image data with known motion types and underlying anatomy, together with retrospective application to sets of clinical acquisitions, are included. Results indicate that this method promises a unique route to acquiring high resolution MRI of the fetal brain in vivo allowing comparable quality to that of neonatal MRI. Such data provides a highly valuable window into the process of normal and abnormal brain development which is directly applicable in a clinical setting.

Mots clés: reconstruction; IRM; recalage; resolution

Domaines: Traitement du signal et de l'image [eess.SP]; Traitement du signal et de l'image [eess.SP]

François Rousseau, Orit Glenn, Bistra Iordanova, Claudia Rodriguez-Carranza, Dan Vigneron, et al.. Registration-based Approach for Reconstruction of High Resolution In Utero Fetal MR Brain Images. Academic Radiology, 2006, 13 (9), pp.1072-1081. ⟨10.1016/j.acra.2006.05.003⟩. ⟨hal-00257196v2⟩