Regulation of the mitogen-activated protein kinases by Brucella spp. expressing a smooth and rough phenotype: relationship to pathogen invasiveness.

María P Jiménez de Bagüés , Antoine Gross (1, 2) , Annie Terraza (1) , Jacques Dornand (1)

1 Microbiologie et Pathologie Cellulaire Infectieuse
2 IRIM - Institut de Recherche en Infectiologie de Montpellier

By comparing smooth wild-type Brucella spp. to their rough mutants, we show that the LPS O chain restricted the activation of the ERK1/2 and p38 mitogen-activated protein kinase (MAPK) pathways, thus preventing the synthesis of immune mediators that regulate host defense. We conclude that the MAPKs are a target for immune intervention by virulent smooth Brucella.

Domaines: Maladies infectieuses; Immunité innée; Bactériologie

María P Jiménez de Bagüés, Antoine Gross, Annie Terraza, Jacques Dornand. Regulation of the mitogen-activated protein kinases by Brucella spp. expressing a smooth and rough phenotype: relationship to pathogen invasiveness.. Infection and Immunity, 2005, 73 (5), pp.3178-83. ⟨10.1128/IAI.73.5.3178-3183.2005⟩. ⟨hal-00194027⟩