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Journal articles

Peptide immobilization on amine-terminated boron-doped diamond surfaces.

Abstract : This paper reports on the formation and characterization of semicarbazide termination on aminated boron-doped diamond (BDD) surfaces, and further prepn. of peptide microarray through site-specific a-oxo semicarbazone ligation. Hydrogen-terminated BDD electrodes were first aminated using NH3 plasma treatment and then reacted with triphosgene and Fmoc-protected (Fmoc = 9-fluorenylmethoxycarbonyl) hydrazine to yield a protected semicarbazide termination. Subsequent deprotection and chem. reaction with glyoxylyl peptides led to the covalent immobilization of the peptides on the surface through site-specific ligation. The resulting surfaces were characterized using XPS and fluorescence measurements.
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Contributor : Leon Gengembre Connect in order to contact the contributor
Submitted on : Tuesday, October 16, 2007 - 3:37:35 PM
Last modification on : Wednesday, March 23, 2022 - 3:50:36 PM

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Leon Gengembre, Rabah Boukherroub, Yannick Coffinier, Didier Delabouglise, Remi Desmet, et al.. Peptide immobilization on amine-terminated boron-doped diamond surfaces.. Langmuir, American Chemical Society, 2007, 23 (8), pp.4494-4497. ⟨10.1021/la063440y⟩. ⟨hal-00179759⟩



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