Variation in FTO contributes to childhood obesity and severe adult obesity.

Christian Dina 1 David Meyre 1 Sophie Gallina 1, 2 Emmanuelle Durand 1, 3, 4, 5, 6 Antje Körner Peter Jacobson Lena M S Carlsson Wieland Kiess Vincent Vatin 1 Cecile Lecoeur 1 Jérome Delplanque Emmanuel Vaillant François Pattou Juan Ruiz 7, 8, 9, 10, 11, 12, 13 Jacques Weill 14, 15 Claire Levy-Marchal Fritz Horber 16 Natascha Potoczna 16 Serge Hercberg 17 Catherine Le Stunff Pierre Bougnères Peter Kovacs Michel Marre 18, 19 Beverley Balkau 20, 21 Stéphane Cauchi 1 Jean-Claude Chèvre Philippe Froguel 1, 22, 23
Abstract : We identified a set of SNPs in the first intron of the FTO (fat mass and obesity associated) gene on chromosome 16q12.2 that is consistently strongly associated with early-onset and severe obesity in both adults and children of European ancestry with an experiment-wise P value of 1.67 x 10(-26) in 2,900 affected individuals and 5,100 controls. The at-risk haplotype yields a proportion of attributable risk of 22% for common obesity. We conclude that FTO contributes to human obesity and hence may be a target for subsequent functional analyses.
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Submitted on : Thursday, September 20, 2007 - 12:24:40 PM
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Christian Dina, David Meyre, Sophie Gallina, Emmanuelle Durand, Antje Körner, et al.. Variation in FTO contributes to childhood obesity and severe adult obesity.. Nature Genetics, Nature Publishing Group, 2007, 39 (6), pp.724-6. ⟨10.1038/ng2048⟩. ⟨hal-00173651⟩

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