Novel chemo-enzymatic access to amphiphilic cyclodextrins

Audrey Favrelle (1, 2) , Véronique Bonnet (2) , Catherine Sarazin (1) , Florence Djedaïni-Pilard (2)

1 GEC - Génie Enzymatique et Cellulaire
2 LG - Laboratoire des Glucides

A new class of mono-substituted amphiphilic cyclodextrins was synthesized in a one-step lipase catalysed amidification. Microbial and animal lipases were able to catalyse this reaction. Depending on the acyl donors, various hydrophobic moieties have been grafted on methylated ß-cyclodextrin. Azoninyl-methylated-ßcyclodextrin derivatives were also obtained by reaction of acetaldehyde and modified cyclodextrins in presence of dedicated lipase.

Mots clés: Amidification; Amphiphilic; Cyclodextrin; Fatty acids; Lipase; Solvent free medium; Vinyl esters

Domaines: Chimie

Audrey Favrelle, Véronique Bonnet, Catherine Sarazin, Florence Djedaïni-Pilard. Novel chemo-enzymatic access to amphiphilic cyclodextrins. The Journal of inclusion Phenomena and Macrocyclic Chemistry, 2007, 57 (1-4), pp.15-20. ⟨10.1007/s10847-006-9167-1⟩. ⟨hal-00172764⟩