Qualitative simulation of the carbon starvation response in Escherichia coli. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue BioSystems Année : 2006

Qualitative simulation of the carbon starvation response in Escherichia coli.

Delphine Ropers
Hidde de Jong
  • Fonction : Auteur
  • PersonId : 831464
Michel Page
  • Fonction : Auteur
Dominique Schneider
  • Fonction : Auteur
  • PersonId : 756490
  • IdRef : 112471048
Johannes Geiselmann
  • Fonction : Auteur

Résumé

In case of nutritional stress, like carbon starvation, Escherichia coli cells abandon their exponential-growth state to enter a more resistant, non-growth state called stationary phase. This growth-phase transition is controlled by a genetic regulatory network integrating various environmental signals. Although E. coli is a paradigm of the bacterial world, it is little understood how its response to carbon starvation conditions emerges from the interactions between the different components of the regulatory network. Using a qualitative method that is able to overcome the current lack of quantitative data on kinetic parameters and molecular concentrations, we model the carbon starvation response network and simulate the response of E. coli cells to carbon deprivation. This allows us to identify essential features of the transition between exponential and stationary phase and to make new predictions on the qualitative system behavior following a carbon upshift.

Dates et versions

hal-00171698 , version 1 (12-09-2007)

Identifiants

Citer

Delphine Ropers, Hidde de Jong, Michel Page, Dominique Schneider, Johannes Geiselmann. Qualitative simulation of the carbon starvation response in Escherichia coli.. BioSystems, 2006, 84 (2), pp.124-52. ⟨10.1016/j.biosystems.2005.10.005⟩. ⟨hal-00171698⟩
115 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More