Synthesis of novel 5-substituted indirubins as protein kinases inhibitors.

Abstract : In an effort to identify new pharmacological inhibitors of disease-relevant protein kinases with increased potency and selectivity, we synthesized and evaluated new 5-substituted indirubins. The effects of 34 indirubin derivatives on CDK1/cyclin B, CDK5/p25, and GSK-3, as well as on SH-SY5Y human neuroblastoma cell survival, were investigated.
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https://hal.archives-ouvertes.fr/hal-00169371
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Submitted on : Monday, September 3, 2007 - 3:23:47 PM
Last modification on : Thursday, February 6, 2020 - 10:30:04 AM

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Anne Beauchard, Yoan Ferandin, Stéphane Frère, Olivier Lozach, Mélina Blairvacq, et al.. Synthesis of novel 5-substituted indirubins as protein kinases inhibitors.. Bioorganic and Medicinal Chemistry, Elsevier, 2006, 14 (18), pp.6434-43. ⟨10.1016/j.bmc.2006.05.036⟩. ⟨hal-00169371⟩

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