Is there a role for antioxidant carotenoids in limiting self-harming immune response in invertebrates? - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Biology Letters Année : 2007

Is there a role for antioxidant carotenoids in limiting self-harming immune response in invertebrates?

Clotilde Biard
Yannick Moret
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Résumé

Innate immunity relies on effectors, which produce cytotoxic molecules that have not only the advantage of killing pathogens but also the disadvantage of harming host tissues and organs. Although the role of dietary antioxidants in invertebrate immunity is still unknown, it has been shown in vertebrates that carotenoids scavenge cytotoxic radicals generated during the immune response. Carotenoids may consequently decrease the self-harming cost of immunity. A positive relationship between the levels of innate immune defence and circulating carotenoid might therefore be expected. Consistent with this hypothesis, we show that the maintenance and use of the prophenoloxidase system strongly correlate with carotenoid concentration in haemolymph within and among natural populations of the crustacean Gammarus pulex.

Dates et versions

hal-00168948 , version 1 (30-08-2007)

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Stéphane Cornet, Clotilde Biard, Yannick Moret. Is there a role for antioxidant carotenoids in limiting self-harming immune response in invertebrates?. Biology Letters, 2007, 3 (3), pp.284-288. ⟨10.1098/rsbl.2007.0003⟩. ⟨hal-00168948⟩
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