Synergic effect of hydride and proton donors in the Pd(0)-mediated deprotection of Nα-Aloc proline derivatives

Abstract : In this study, the challenging Pd(0)-catalyzed Nα-Aloc removal from a proline residue using Me2NH·BH3 or PhSiH3 as allyl scavengers has been investigated. Standard conditions led to a large amount of an allylamine byproduct. A careful study of the reactions allowed us to design the optimal conditions for the quick and quantitative formation of the desired product, while taking advantage of a synergic effect between hydride and proton donors.
Document type :
Journal articles
Complete list of metadatas

https://hal.archives-ouvertes.fr/hal-00166600
Contributor : Isabelle Frapart <>
Submitted on : Tuesday, August 7, 2007 - 3:37:29 PM
Last modification on : Tuesday, June 4, 2019 - 4:30:11 PM

Identifiers

Collections

Citation

Isidore P. Decostaire, Dominique Lelièvre, Vincent Aucagne, Agnès F. Delmas. Synergic effect of hydride and proton donors in the Pd(0)-mediated deprotection of Nα-Aloc proline derivatives. Tetrahedron Letters, Elsevier, 2007, 48, pp.6523-6526. ⟨10.1016/j.tetlet.2007.07.061⟩. ⟨hal-00166600⟩

Share

Metrics

Record views

54