Skip to Main content Skip to Navigation
Journal articles

The intracellular fate of Salmonella depends on the recruitment of kinesin.

Abstract : Salmonella enterica causes a variety of diseases, including gastroenteritis and typhoid fever. The success of this pathogen depends on its capacity to proliferate within host cells in a membrane-bound compartment. We found that the Salmonella-containing vacuole recruited the plus-end-directed motor kinesin. Bacterial effector proteins translocated into the host cell by a type III secretion system antagonistically regulated this event. Among these effectors, SifA targeted SKIP, a host protein that down-regulated the recruitment of kinesin on the bacterial vacuole and, in turn, controlled vacuolar membrane dynamics.
Document type :
Journal articles
Complete list of metadata

https://hal.archives-ouvertes.fr/hal-00165696
Contributor : Marie Laure Haon Connect in order to contact the contributor
Submitted on : Friday, July 27, 2007 - 11:35:47 AM
Last modification on : Monday, May 9, 2022 - 11:58:07 AM

Identifiers

Collections

Citation

Emmanuel Boucrot, Thomas Henry, Jean-Paul Borg, Jean-Pierre Gorvel, Stéphane Méresse. The intracellular fate of Salmonella depends on the recruitment of kinesin.. Science, American Association for the Advancement of Science (AAAS), 2005, 308 (5725), pp.1174-8. ⟨10.1126/science.1110225⟩. ⟨hal-00165696⟩

Share

Metrics

Record views

14