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Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor gamma activity.

Abstract : Colitis involves immune cell-mediated tissue injuries, but the contribution of epithelial cells remains largely unclear. Vanin-1 is an epithelial ectoenzyme with a pantetheinase activity that provides cysteamine/cystamine to tissue. Using the 2,4,6-trinitrobenzene sulfonic acid (TNBS)-colitis model we show here that Vanin-1 deficiency protects from colitis. This protection is reversible by administration of cystamine or bisphenol A diglycidyl ether, a peroxisome proliferator-activated receptor (PPAR)gamma antagonist. We further demonstrate that Vanin-1, by antagonizing PPARgamma, licenses the production of inflammatory mediators by intestinal epithelial cells. We propose that Vanin-1 is an epithelial sensor of stress that exerts a dominant control over innate immune responses in tissue. Thus, the Vanin-1/pantetheinase activity might be a new target for therapeutic intervention in inflammatory bowel disease.
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https://hal.archives-ouvertes.fr/hal-00165626
Contributor : Marie Laure Haon <>
Submitted on : Thursday, July 26, 2007 - 5:34:50 PM
Last modification on : Thursday, November 26, 2020 - 3:08:48 AM

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Carole Berruyer, Laurent Pouyet, Virginie Millet, Florent M Martin, Aude Legoffic, et al.. Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor gamma activity.. Journal of Experimental Medicine, Rockefeller University Press, 2006, 203 (13), pp.2817-27. ⟨10.1084/jem.20061640⟩. ⟨hal-00165626⟩

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