Cyclo-(DfKRG) peptide grafting onto Ti–6Al–4V: physical characterization and interest towards human osteoprogenitor cells adhesion

Marie-Christine Porté-Durrieu (1) , Fabien Guillemot (1) , S. Pallu (1) , Christine Labrugère (2) , B. Brouillaud (1, 3) , Reine Bareille (1) , Joëlle Amédée (1) , Nicole Barthe (1, 3) , M. Dard (4) , Charles Baquey (1, 3)

1 Biomateriaux et Reparation Tissulaire
2 ICMCB - Institut de Chimie de la Matière Condensée de Bordeaux
3 Laboratoire de Biophysique
4 Biomet-Merck Biomaterials

In the present paper, specific interest has been devoted to the design of new hybrid materials associating Ti–6Al–4V alloy and osteoprogenitor cells through the grafting of two RGD containing peptides displaying a different conformation (linear RGD and cyclo-DfKRG) onto titanium surface. Biomimetic modification was performed by means of a three-step reaction procedure: silanization with APTES, cross-linking with SMP and finally immobilization of peptides thanks to thiol bonding...

Mots clés: Biomimetic material; Titanium alloy; RGD peptide; Cell adhesion

Domaines: Matériaux

Marie-Christine Porté-Durrieu, Fabien Guillemot, S. Pallu, Christine Labrugère, B. Brouillaud, et al.. Cyclo-(DfKRG) peptide grafting onto Ti–6Al–4V: physical characterization and interest towards human osteoprogenitor cells adhesion. Biomaterials, 2004, 25 (19), pp.4837-4846. ⟨10.1016/j.biomaterials.2003.11.037⟩. ⟨hal-00158776⟩