Simultaneous presence of unsatuation and long alkyl chain at P'1 of ilomastat confers selectivity for gelatinase A (MMP-2) over gelatinase B (MMP-9= inhibition as shown by molecular modelling studies

Gauthier Moroy (1) , Clément Denhez (2) , Haquima El Mourabit (3) , Alix Toribio (2) , Alexandra Dassonville (2) , Martine Decarme (3) , Jean-Hugues Renault (2) , Catherine Mirand (2) , Georges Bellon (3) , Janos Sapi (2) , Alain J.P. Alix (1) , William Hornebeck (3) , Erika Bourguet (2)

1 URCA - Université de Reims Champagne-Ardenne
2 ISTSSN - Isolement, structure, transformations et synthèse de substances naturelles
3 MERC - Matrice extracellulaire et régulations cellulaires

Gauthier Moroy, Clément Denhez, Haquima El Mourabit, Alix Toribio, Alexandra Dassonville, et al.. Simultaneous presence of unsatuation and long alkyl chain at P'1 of ilomastat confers selectivity for gelatinase A (MMP-2) over gelatinase B (MMP-9= inhibition as shown by molecular modelling studies. Bioorganic and Medicinal Chemistry, 2007, 15, pp.4753-4766. ⟨hal-00157962⟩