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Genome sequence of Aedes aegypti, a major arbovirus vector.

Vishvanath Nene 1 Jennifer R. Wortman 1 Daniel Lawson 2 Brian Haas 1 Chinnappa Kodira 3 Zhijian Jake Tu 4 Brendan Loftus 1, 5 Zhijong Xi 6 Karyn Megy 2 Manfred Grabherr 3 Quinghu Ren 1 Evgeny M. Zdobnov 7 Neil F. Lobo 8 Kathryn S. Campbell 9 Susan E. Brown 10 Maria F. Bonaldo 11 Jingsong Zhu 12 Steven P. Sinkins 13 David G. Hogenkamp 14 Paulo Amedo 1 Peter Arsenburger 12 Peter W. Atkinson 12 Shelby Bidwell 1 Jim Biedler 4 Ewan Birney 2 Robert V. Bruggner 8 Javier Costas 15 Monique R. Coy 4 Jonathan Crabtree 1 Matt Crawford 3 Becky Debruyn 8 David Decaprio 3 Karin Eiglmeier 16 Eric Eisenstadt 1 Hamza El-Dorry 17 William M. Gelbar 9 Suely L. Gomes 17 Martin Hammond 2 Linda I. Hannick 1 James R. Hogan 8 Michael H. Holmes 1 David Jaffe 3 Spencer J. Johnston 18 Ryan C. Kennedy 8 Hean Koo 1 Saul Kravitz 19 Evgenia V. Kriventseva 20 David Kulp 21 Kurt Labutti 3 Edward Lee 1 Song Li 4 Diane D. Lovin 8 Chunhong Mao 4 Evan Mauceli 3 Carlos F. M. Menck 22 Jason R. Miller 1 Philip Montgomery 3 Akio Mori 8 Ana L. Nascimento 23 Horacio F. Naveira 24 Chad Nusbaum 3 Sinéad B. O'Leary 3 Joshua Orvis 1 Mihaela Pertea 25 Hadi Quesneville 26 Kyanne R. Reidenbach 14 yu-Hui Rogers 19 Charles W. Roth 16 Jennifer R. Schneider 8 Michael Schatz 25 Martin Shumway 1 Mario Stanke 27 Eric O. Stinson 8 Jose M. C. Tubio 28 Janice P. Vanzee 14 Sergio Verjovski-Almeida 17 Doreen Werner 29 Owen White 1 Stefan Wyder 20 Qi Zeng 3 Qi Zhao 1 yongmei Zhao 1 Catherine A. Hill 14 Alexander S. Raikhel 12 Marcelo B. Soares 11 Dennis L. Knudson 10 Norman H. Lee 30 James Galagan 3 Steven L. Salzberg 25 Ian T. Paulsen 1 George Dimopoulos 6 Frank H. Collins 8 Birren Bruce 3 Claire M. Fraser-Liggett 1 David W. Severson 8 
Abstract : We present a draft sequence of the genome of Aedes aegypti, the primary vector for yellow fever and dengue fever, which at approximately 1376 million base pairs is about 5 times the size of the genome of the malaria vector Anopheles gambiae. Nearly 50% of the Ae. aegypti genome consists of transposable elements. These contribute to a factor of approximately 4 to 6 increase in average gene length and in sizes of intergenic regions relative to An. gambiae and Drosophila melanogaster. Nonetheless, chromosomal synteny is generally maintained among all three insects, although conservation of orthologous gene order is higher (by a factor of approximately 2) between the mosquito species than between either of them and the fruit fly. An increase in genes encoding odorant binding, cytochrome P450, and cuticle domains relative to An. gambiae suggests that members of these protein families underpin some of the biological differences between the two mosquito species.
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https://hal.archives-ouvertes.fr/hal-00156214
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Submitted on : Wednesday, June 20, 2007 - 12:29:41 PM
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Vishvanath Nene, Jennifer R. Wortman, Daniel Lawson, Brian Haas, Chinnappa Kodira, et al.. Genome sequence of Aedes aegypti, a major arbovirus vector.. Science, American Association for the Advancement of Science (AAAS), 2007, 316 (5832), pp.1718-23. ⟨10.1126/science.1138878⟩. ⟨hal-00156214⟩

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