A Novel Drug Delivery System for Bisphosphonates : Innovative Strategy for Local Treatment of Bone Resorption

S. Josse (1) , C. Faucheux (2) , A. Soueidan (2) , G. Grimandi (2) , D. Massiot (3, 4) , B. Alonso (3, 4) , P. Janvier (1) , S. Laïb (1) , J. Guicheux (2) , B. Bujoli (1) , J.M. Bouler (2)

1 LSOHOOM - Laboratoire de Synthèse Organique (Hétérochimie organique, organoéléments et matériaux)
2 LIOAD - Laboratoire d'ingénierie osteo-articulaire et dentaire
3 CRMHT - Centre de recherches sur les matériaux à haute température
4 FRMN-SHC - Fédération RMN du Solide à Hauts Champs

One type of potent aminobisphosphonate (Zoledronate) has been chemically associated onto b-tricalcium phosphate [b-TCP] and calcium deficients apatite [CDA]. Two different association modes have been observed, according to the nature of the Calcium Phosphate [CaP] support and/or the initial concentration of the Zoledronate solution. b-TCP appears to promote Zoledronate-containing crystals formation. On the other hand, at concentrations < 0.05 mol.L-1 CDA seems to undergo chemisorption of the drug through a surface adsorption process, due to PO3 for PO4 exchange, which is well described by Freundlich equations. At concentrations > 0.05 mol.L-1, crystalline needles of a Zoledronate complex form onto the CDA surface. The ability of CDA to release Zoledronate, resulting in the inhibition of osteoclastic activity, was shown using a specific in vitro bone resorption model.

Domaines: Matériaux

S. Josse, C. Faucheux, A. Soueidan, G. Grimandi, D. Massiot, et al.. A Novel Drug Delivery System for Bisphosphonates : Innovative Strategy for Local Treatment of Bone Resorption. Key Engineering Materials, 2005, 284, pp.399-402. ⟨hal-00154588⟩