Neuronal and muscular alterations caused by two wheat endosperm proteins, puroindoline-a and alpha1-purothionin, are due to ion pore formation.

Paola Llanos (1) , Mauricio Henriquez (1) , Jasmina Minic (2, 3) , Khalil Elmorjani (4) , Didier Marion (4) , Gloria Riquelme (1) , Jordi Molgó (2, 3) , Evelyne Benoit (2, 3)

1 Instituto de Ciencias Biomédicas
2 NBCM - Laboratoire de neurobiologie cellulaire et moléculaire
3 INAF - Institut de Neurobiologie Alfred Fessard
4 BIA - Unité de recherche sur les Biopolymères, Interactions Assemblages

Using the patch-clamp technique it was found that the toxicity of the two wheat endosperm proteins puroindoline-a and alpha1-purothionin probably results from the dissipation of ion concentration gradients essential for the maintenance of cellular homeostasis.

Mots clés: Giant liposomes; Mouse neuromuscular junction; Neuroblastoma cells; Pore formation; Wheat endosperm proteins

Domaines: Neurosciences [q-bio.NC]; Neurobiologie

Paola Llanos, Mauricio Henriquez, Jasmina Minic, Khalil Elmorjani, Didier Marion, et al.. Neuronal and muscular alterations caused by two wheat endosperm proteins, puroindoline-a and alpha1-purothionin, are due to ion pore formation.. European Biophysics Journal, 2004, 33 (3), pp.283-284. ⟨10.1007/s00249-003-0353-4⟩. ⟨hal-00139885⟩