PAMAM dendrimers for efficient siRNA delivery and potent gene silencing

J. Zhou , J. Wu , N. Hafdi , J.-P. Behr (1) , P. Erbacher , Ling Peng (2)

1 Institut Gilbert-Laustriat : Biomolécules, Biotechnologie, Innovation Thérapeutique
2 GCOMM - Groupe de chimie organique et matériaux moléculaires

Genuine, nondegraded PAMAM dendrimers self-assemble with siRNA into nanoscale particles that are efficient for siRNA delivery and induce potent endogenous gene silencing.

Domaines: Chimie

J. Zhou, J. Wu, N. Hafdi, J.-P. Behr, P. Erbacher, et al.. PAMAM dendrimers for efficient siRNA delivery and potent gene silencing. Chemical Communications, 2006, 22, pp.2362-2364. ⟨10.1039/B601381C⟩. ⟨hal-00130018⟩