Poly(ADP-ribose): novel functions for an old molecule
Résumé
The addition to proteins of the negatively charged polymer of ADP-ribose (PAR), which is synthesized by PAR polymerases (PARPs) from NAD(+), is a unique post-translational modification. It regulates not only cell survival and cell-death programmes, but also an increasing number of other biological functions with which novel members of the PARP family have been associated. These functions include transcriptional regulation, telomere cohesion and mitotic spindle formation during cell division, intracellular trafficking and energy metabolism.
Mots clés
Animals
Cell Death/physiology
Cell Division/physiology
DNA Damage
DNA Repair
Diphtheria Toxin/chemistry
Humans
Inflammation/metabolism
Models
Molecular
Multigene Family
NAD/biosynthesis
Poly Adenosine Diphosphate Ribose/chemistry/genetics/*metabolism
Poly(ADP-ribose) Polymerases/chemistry/genetics/*metabolism
Protein Conformation
Protein Isoforms/chemistry/genetics/*metabolism
Research Support
Non-U.S. Gov't