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LTS cells in cerebral cortex and their role in generating spike-and-wave oscillations.

Abstract : Some types of epileptic seizures involve both thalamus and cerebral cortex, while other types can be evoked in the cerebral cortex without thalamic participation. We investigated the possible role of low-threshold spike (LTS) cortical neurons in the genesis of these intracortical seizures. We found LTS cortical neurons in cat area 5–7 in vivo, the properties of which could be modeled based on relatively weak densities of the T-type calcium channel. At the network level, a small minority of LTS pyramidal cells was sufficient to generate paroxysmal oscillations with spike-and-wave (SW) field potentials. These oscillations reproduce the properties of intracortical SW paroxysms observed in athalamic cats, such as the slow frequency (1.8–2.5 Hz). We suggest that calcium-mediated rebound mechanisms intrinsic to cerebral cortex can explain the genesis of intracortical SW activity.
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Contributor : Alain Perignon Connect in order to contact the contributor
Submitted on : Monday, January 15, 2007 - 4:36:08 PM
Last modification on : Monday, July 20, 2020 - 1:06:04 PM

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Alain Destexhe, Diego Contreras, Mircea Steriade. LTS cells in cerebral cortex and their role in generating spike-and-wave oscillations.. Neurocomputing, Elsevier, 2001, 38-40, pp.555-563. ⟨10.1016/S0925-2312(01)00348-4⟩. ⟨hal-00124657⟩



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