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EBV-associated nasopharyngeal carcinomas: from epidemiology to virus-targeting strategies.

Pierre Busson 1 C. Keryer 1 T. Ooka 2, * M. Corbex 3 
* Corresponding author
1 IMC (UMR 8126) - Interactions moléculaires et cancer
UMR8126 - Signalisation, noyaux et innovations en cancérologie
Abstract : Nasopharyngeal carcinoma is a human malignancy consistently associated with the Epstein-Barr virus. Exposure to non-viral carcinogens and genetic predisposition are other crucial etiologic factors. Tumor development appears to require the expression of a small subset of transforming viral RNAs and proteins with concomitant silencing of most other viral genes. Impairment of the interactions of viral proteins with cellular partners or disruption of viral latency might prove to be useful for novel therapeutic strategies.
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https://hal.archives-ouvertes.fr/hal-00122928
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Submitted on : Friday, January 5, 2007 - 4:37:12 PM
Last modification on : Tuesday, December 29, 2020 - 1:30:02 PM

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  • HAL Id : hal-00122928, version 1
  • PUBMED : 15276610

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Pierre Busson, C. Keryer, T. Ooka, M. Corbex. EBV-associated nasopharyngeal carcinomas: from epidemiology to virus-targeting strategies.. Trends Microbiol, 2004, pp.360. ⟨hal-00122928⟩

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