Functionalized luminescent oxide nanoparticles for sodium channel imaging at the single molecule level

Abstract : Lanthanide-ion doped oxide nanoparticles were functionalized for use as fluorescent biological labels. These nanoparticles are synthesized directly in water which facilitates their functionalization, and are very photostable without emission intermittency. Nanoparticles functionalized with guanidinium groups act as artificial toxins and specifically target sodium channels. They are individually detectable in cardiac myocytes, revealing a heterogeneous distribution of sodium channels. Functionalized oxide nanoparticles appear as a novel tool particularly well adapted to long-term single-molecule tracking. © (2005) COPYRIGHT SPIE--The International Society for Optical Engineering
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https://hal.archives-ouvertes.fr/hal-00102790
Contributor : Laure Lachapelle <>
Submitted on : Monday, October 2, 2006 - 4:23:55 PM
Last modification on : Wednesday, March 27, 2019 - 4:18:01 PM

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Didier Casanova, D. Giaume, Emmanuel Beaurepaire, Martin-Pierre Sauviat, Egidijus Auksorius, et al.. Functionalized luminescent oxide nanoparticles for sodium channel imaging at the single molecule level. Nanobiophotonics and Biomedical Applications II, Jan 2005, San José, United States. ⟨10.1117/12.590737⟩. ⟨hal-00102790⟩

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