Neurotoxicity and other pharmacological activities of the snake venom phospholipase A2 OS2: the N-terminal region is more important than enzymatic activity

M. Rouault (1) , L.D. Rash (1) , P. Escoubas (1) , E. Boilard (1) , J. Bollinger (2) , B. Lomonte (3) , T. Maurin (4) , C. Guillaume (5) , Stéphane Canaan (6) , C. Deregnaucourt (5) , J. Schrevel (5) , A. Doglio (4) , J.M. Gutierrez (3) , M. Lazdunski (1) , M. H. Gelb (2) , G. Lambeau (1)

1 IPMC - Institut de pharmacologie moléculaire et cellulaire
2 Departements of Chemistry and Biochemistry
3 Faculdad de Microbiologia, Instituto Clodomiro Picado
4 GSM - Génétique et signalisation moléculaire
5 MCAM - Molécules de Communication et Adaptation des Micro-Organismes
6 EIPL - Laboratoire Enzymologie Interfaciale et de Physiologie de la Lipolyse - UPR9025

Domaines: Sciences du Vivant [q-bio]; Biochimie, Biologie Moléculaire; Biologie cellulaire

M. Rouault, L.D. Rash, P. Escoubas, E. Boilard, J. Bollinger, et al.. Neurotoxicity and other pharmacological activities of the snake venom phospholipase A2 OS2: the N-terminal region is more important than enzymatic activity. Biochemistry, 2006, 45, pp.5800-5816. ⟨hal-00091184⟩