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Global trends of whole genome duplications revealed by the genome sequence of the ciliate Paramecium tetraurelia

Jean-Marc Aury Olivier Jaillon * Laurent Duret Benjamin Noel Claire Jubin Betina M. Porcel Béatrice Ségurens Vincent Daubin Véronique Anthouard Nathalie Aiach Olivier Arnaiz Alain Billaut Janine Beisson Isabelle Blanc Khaled Bouhouche 1 Francisco Câmara Sandra Duharcourt 1 Roderic Guigo Delphine Gogendeau Michael Katinka Anne-Marie Keller Roland Kissmehl Catherine Klotz France Koll Anne Le Mouël 1 Gersende Lepère 1 Sophie Malinsky 1 Mariusz Nowacki 1 Jacek K. Nowak Helmut Plattner Julie Poulain 2 Françoise Ruiz Vincent Serrano 1 Marek Zagulski Philippe Dessen Mireille Bétermier 1 Jean Weissenbach 3 Claude Scarpelli Vincent Schächter Linda Sperlin Eric Meyer 1 Jean Cohen Patrick Wincker 4
1 REG - Régulation de l'expression génétique
2 UMR 8030 - Génomique métabolique
3 IG - Institut de Génomique d'Evry
4 GENOSCOPE - Genoscope - Centre national de séquençage [Evry]
Abstract : The duplication of entire genomes has long been recognized as having great potential for evolutionary novelties, but the mechanisms underlying their resolution through gene loss are poorly understood. Here we show that in the unicellular eukaryote Paramecium tetraurelia, a ciliate, most of the nearly 40,000 genes arose through at least three successive whole-genome duplications. Phylogenetic analysis indicates that the most recent duplication coincides with an explosion of speciation events that gave rise to the P. aurelia complex of 15 sibling species. We observed that gene loss occurs over a long timescale, not as an initial massive event. Genes from the same metabolic pathway or protein complex have common patterns of gene loss, and highly expressed genes are over-retained after all duplications. The conclusion of this analysis is that many genes are maintained after whole-genome duplication not because of functional innovation but because of gene dosage constraints.
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https://hal.archives-ouvertes.fr/hal-00090904
Contributor : Martine Duponchelle <>
Submitted on : Monday, September 4, 2006 - 12:56:26 PM
Last modification on : Thursday, July 8, 2021 - 3:49:00 AM

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CNRS | CEA | GENOSCOPE | JACOB | CEA-DRF | UNIV-EVRY | GENOMIQUE-METABOLIQUE | PSL

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Jean-Marc Aury, Olivier Jaillon, * Laurent Duret, Benjamin Noel, Claire Jubin, et al.. Global trends of whole genome duplications revealed by the genome sequence of the ciliate Paramecium tetraurelia. Nature, Nature Publishing Group, 2006, 444 (7116), pp.171-178. ⟨10.1038/nature05230⟩. ⟨hal-00090904⟩

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