Practical considerations for pharmaceutical antibody production in different crop systems.

E. Stoger , M. Sack , Y. Perrin (1) , C. Vaquero , E. Torres , R.M. Twyman , P. Christou , R. Fischer

1 GEC - Génie Enzymatique et Cellulaire

The potential of plant cells to produce functional recombinantantibodies has been demonstrated in a number of different plant systems. Wepresent a comparative study of a well-defined target protein, a single chain Fvantibody, in different transgenic crop species and cultured tissues. The effectof different regulatory elements and signals for subcellular targeting areconsidered. Practical considerations for the choice of a particular cropsystem,such as yield, storage, distribution and containment properties are discussed.

E. Stoger, M. Sack, Y. Perrin, C. Vaquero, E. Torres, et al.. Practical considerations for pharmaceutical antibody production in different crop systems.. Molecular Breeding, 2003, 9, pp.149-158. ⟨hal-00086176⟩