Molecularly imprinted polymers : Artificial receptors for affinity separations.
Résumé
The technique of molecular imprinting allows for the formation of specific recognition sites in synthetic polymers through the use of templates or imprint molecules. These recognition sites mimic the binding sites of biological receptors like antibodies and enzymes. The result is known as a molecularly imprinted polymer (MIP) or imprinted phase. An MIP can potentially be used in any application that requires a specific binding event, such as an affinity separation, a binding assay, or a biosensor. MIPs also have possible uses in organic synthesis and catalysis. The stability, ease of preparation, and low cost of MIPs make them particularly attractive for these applications. This chapter focuses on recent developments in molecular imprinting and the applications of MIPs in affinity separations and related techniques.