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RGM and its receptor neogenin regulate neuronal survival.

Abstract : Repulsive guidance molecule (RGM) is an axon guidance protein that repels retinal axons upon activation of the neogenin receptor. To understand the functions of RGM-neogenin complexes in vivo, we used gene transfer technology to perturb their expression in the developing neural tube of chick embryos. Surprisingly, neogenin over-expression or RGM down-expression in the neural tube induces apoptosis. Neogenin pro-apoptotic activity in immortalized neuronal cells and in the neural tube is associated with the cleavage of its cytoplasmic domain by caspases. Thus neogenin is a dependence receptor inducing cell death in the absence of RGM, whereas the presence of RGM inhibits this effect.
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Contributor : Therese Ghembaza <>
Submitted on : Monday, June 19, 2006 - 4:05:28 PM
Last modification on : Tuesday, December 15, 2020 - 4:01:46 AM

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E. Matsunaga, S. Tauszig-Delamasure, P.P. Monnier, B.K. Mueller, S.M. Strittmatter, et al.. RGM and its receptor neogenin regulate neuronal survival.. Nature Cell Biology, Nature Publishing Group, 2004, 6, pp.749-755. ⟨10.1038/ncb1157⟩. ⟨hal-00080594⟩



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