An efficient chemoenzymatic route to dihydroxyacetone phosphate from glycidol for the in situ aldoalse-mediated synthesis of monosaccharides

Franck Charmantray (1) , Philippe Dellis , Soth Samreth , Laurence Hecquet (1)

1 SEESIB - Synthèse et étude de systèmes à intêret biologique

We report a new two-step procedure that uses inexpensive rac-glycidol to obtain valuable dihydroxyacetone phosphate (DHAP), a building block for the synthesis of monosaccharide analogues.

Mots clés: DHAP; Multienzymatic synthesis; Aldolase; C-C Bond formation

Domaines: Chimie organique

Franck Charmantray, Philippe Dellis, Soth Samreth, Laurence Hecquet. An efficient chemoenzymatic route to dihydroxyacetone phosphate from glycidol for the in situ aldoalse-mediated synthesis of monosaccharides. Tetrahedron Letters, 2006, 47, pp.3261-3263. ⟨10.1016/j.tetlet.2006.03.036⟩. ⟨hal-00022357⟩