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Article Dans Une Revue HYBRIDOMA Année : 2005

Antitumor response against myeloma cells by immunization with mouse syngenic dentritoma

C.O. Sarde
  • Fonction : Auteur
J. Kadouche
  • Fonction : Auteur

Résumé

In order to generate an immune response against myeloma cells in an homogenous murine model, a stable hybrid cell line (DCSp) was established through the syngenic fusion between mouse dendritic cells (DC) and mouse Sp2/0 myeloma cells. DCSp cells behaved as potent T cell stimulators and were able to induce Sp2/0 specific cytotoxicity. When mice were immunized with irradiated hybrids before SP2/0 injection, they exhibited a significantly higher rate of survival as compared with controls. When tumors were detected, their emergence was not delayed, and time elapsed between tumor clinical perception and death remained unchanged. A humoral immune response was also always associated. We assume that this stable dendritoma cell line can be considered a valuable tool for myeloma studies in an homogenous mouse model. The efficiency of dendritoma as a weapon against tumor cells and the benefit of syngeny in experimental models are discussed.
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Dates et versions

hal-00016747 , version 1 (10-01-2006)

Identifiants

Citer

S. Queant, C.O. Sarde, M.G. Gobert, J. Kadouche, A. Roseto. Antitumor response against myeloma cells by immunization with mouse syngenic dentritoma. HYBRIDOMA, 2005, 24, pp.182-188. ⟨10.1089/hyb.2005.24.182⟩. ⟨hal-00016747⟩
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