Synthesis of pyridino[3',2' :4,5]pyrrolo[3,2-g]pyrrolo-[3,4-e]indolizin-1,3-dione and pyrrolo[3,2-c]pyrazole skeletons

Fabrice Anizon (1) , Bruno Pfeiffer (1) , Michelle Prudhomme (1)

1 SEESIB - Synthèse et étude de systèmes à intêret biologique

A three step synthesis of an isogranulatimide analogue, in which the imidazole moiety is replaced by a pyrrole unit and the indole heterocycle is replaced by a 7-azaindole moiety is described. Moreover, a novel synthetic pathway to the pyrrolo[3,2-c]pyrazole skeleton is reported

Mots clés: Isogranulatimide; Antitumor agents; G2 Checkpoint inhibitors; 7-Azaindole; Pyrrolo[3; 2-c]pyrazole

Domaines: Chimie organique

Fabrice Anizon, Bruno Pfeiffer, Michelle Prudhomme. Synthesis of pyridino[3',2' :4,5]pyrrolo[3,2-g]pyrrolo-[3,4-e]indolizin-1,3-dione and pyrrolo[3,2-c]pyrazole skeletons. Tetrahedron Letters, 2006, 47, pp.433-436. ⟨10.1016/j.tetlet.2005.11.076⟩. ⟨hal-00016530⟩