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Chapitre D'ouvrage Année : 2005

Fusome as a Cell-Cell Communication Channel of Drosophila Ovarian Cyst

Jean-René Huynh

Résumé

In most animal species, female and male gametes are produced within clusters of germ cells which share a common cytoplasm through cell-cell channels. In Drosophila ovaries, these cells synchronise their divisions and specialise one cell of the cluster as the future egg. Both processes are organised by a germline-specific organelle of communication called the fusome. Until recently, the fusome has remained largely mysterious despite a hundred years of research on its composition, formation and functions. Novel results have now suggested several molecular mechanisms to explain how the fusome synchronises the divisions by controlling cell-cycle regulators and how it determines and polarises the future egg by organising the microtubule cytoskeleton. Importantly, a structure similar to the fusome has been identified during Xenopus oogenesis, suggesting that it is widely conserved from invertebrates to vertebrates, and that it thus serves an essential function.
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Dates et versions

hal-00013440 , version 1 (08-02-2006)

Identifiants

  • HAL Id : hal-00013440 , version 1

Citer

Jean-René Huynh. Fusome as a Cell-Cell Communication Channel of Drosophila Ovarian Cyst. F. Baluska, D. Volkmann & P.W. Barlow. Cell-Cell Channels, Landes Biosciences, sous presse, 2005. ⟨hal-00013440⟩
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