Novel biomaterials for bisphosphonate delivery.

Solen Josse , Corine Faucheux , A. Soueidan , Gaël Grimandi , Dominique Massiot (1) , Bruno Alonso (1) , Pascal Janvier , Samia Laïb , Paul Pilet , Olivier Gauthier , Guy Daculsi , Jérome Guicheux , Bruno Bujoli (2) , Jean-Michel Bouler

1 CRMHT - Centre de recherches sur les matériaux à haute température
2 LSOHOOM - Laboratoire de Synthèse Organique (Hétérochimie organique, organoéléments et matériaux)

One type of gem-bisphosphonate (Zoledronate) has been chemically associated onto calcium phosphate (CaP) compounds of various compositions. For that purpose,CaP powders of controlled granulometry have been suspended in aqueous Zoledronate solutions of variable concentrations. Using mainly 31P NMR spectroscopy,two different association modes have been observed, according to the nature of the CaP support and/or the initial concentration of the Zoledronate solution. b-tricalcium phosphate (b- TCP) and mixtures of hydroxyapatite and b-TCP (BCPs) appear to promote Zoledronate-containing crystals formation. On the other hand,at concentrations o0.05 mol l1 CDAs (calcium deficients apatites) seem to undergo chemisorption of the drug through a surface adsorption process,due to PO3 for PO4 exchange,that is well described by Freundlich equations. At concentrations >0.05 mol l1,crystalline needles of a Zoledronate complex form onto the CDAs surface. The ability of such materials to release Zoledronate,resulting in the inhibition of osteoclastic activity,was shown using a specific in vitro bone resorption model.

Solen Josse, Corine Faucheux, A. Soueidan, Gaël Grimandi, Dominique Massiot, et al.. Novel biomaterials for bisphosphonate delivery.. Biomaterials, 2005, 26, pp.2073-2080. ⟨10.1016/j.biomaterials.2004.05.019⟩. ⟨hal-00012225⟩