G. Kraft and K. Langbein, In 6 th Workshop on heavy charged particles in biology and medicine, GSI Report, pp.97-106, 1998.

C. Champion, Structure des dépôts d'énergie des ions rapides dans l'eau : Application à l'étude par simulation Monte Carlo de l'inactivation cellulaire, Thèse de 3 ème cycle, 1999.

F. Grémy and J. Perrin, Eléments de Biophysique, Tomes I et II, Flammarion Médecine-Sciences, 1997.

R. L. Warters, K. G. Hofer, C. R. Harris, and S. J. , Radionucleide toxicity in cultured mammalian cells: elucidation of the primary site of radiation damage, Curr. Top. Radiat. Res. Quart, p.12, 1977.

G. W. Barendsen, H. M. Walter, J. F. Fowler, and D. K. Bewley, Effects of different ionizing radiations on human cells in tissue culture, Radiat. Res, p.18, 1963.

R. K. Sachs, A. M. Chen, and D. J. Brenner, Review: proximity effects in the production of chromosome aberrations by ionizing radiation, Int. J. Radiat. Biol, p.71, 1997.

G. Kraft, Radiobiology of very heavy ions: inactivation, induction of chromosome aberrations and strand breaks, Nucl. Sci. Appl, vol.3, 1987.

B. Rydberg, M. Löbrich, and C. P. , Repair of clustered DNA damage caused by high LET radiation in human fibroblasts, In 6 th Workshop on heavy charged particles in biology and medicine, Physica Medica, 1998.

M. Belli, F. Ceras, R. Cherubini, F. Ianzini, G. Moschini et al., DNA Double-strand Breaks Induced by Low Energy Protons in V79 Cells, International Journal of Radiation Biology, vol.35, issue.5, p.65, 1994.
DOI : 10.1080/09553009414550621

M. Folkard, K. M. Prise, B. Vojnovic, H. C. Newman, M. J. Roper et al., Inactivation of V79 cells by low-energy protons, deuterons and helium-3 ions, International Journal of Radiation Biology, vol.49, issue.6, p.69, 1996.
DOI : 10.1080/095530096145472

M. M. Elkind, Repair Processes in Radiation Biology, Failla Memorial Lecture, 1984.
DOI : 10.2307/3576409

M. Z. Zdzienicka, N. V. Wessel, and S. G. , A fourth complementation group among ionization radiation-sensitive chinese hamster mutants defect in DNA double strand break repair, Radiat. Res, p.131, 1992.

J. F. Ward, Mechanisms of DNA repair and their potential modification for radiotherapy, International Journal of Radiation Oncology*Biology*Physics, vol.12, issue.7, p.12, 1986.
DOI : 10.1016/0360-3016(86)90220-8

J. L. Coatrieux, On-Line Electromyographic Signal Processing System, IEEE Transactions on Biomedical Engineering, vol.31, issue.2, pp.199-207, 1984.
DOI : 10.1109/TBME.1984.325329

J. Bancaud, J. Talairach, A. Bonis, C. Schaub, G. Szikla et al., La stéréoelectroencéphalographie dans l'épilepsie: informations neurophysio-pathologiques apportées par l'investigation fonctionnelle stéréotaxique, 1965.

H. Leman, C. Marque, and J. Gondry, Use of the electrohysterogram signal for characterization of contractions during pregnancy, IEEE Transactions on Biomedical Engineering, vol.46, issue.10, pp.1222-1229, 1999.
DOI : 10.1109/10.790499

L. G. Durand, P. Pibarot, A. I. Hernandez, G. Carrault, F. Mora et al., Digital Signal Processing of the Phonocardiogram: Review of the Most Recent Advancements, Commande et Communication" (IC2), Editions Hermès, pp.163-219, 1995.
DOI : 10.1615/CritRevBiomedEng.v23.i3-4.10

B. Escoffier, Analyses factorielles simples et multiples: objectifs, méthodes et interprétations, Dunod

M. Basseville and I. Nikiforov, Detection of abrupt changes: theory and application, 1993.
URL : https://hal.archives-ouvertes.fr/hal-00008518

L. Senhadji and J. Duchêne, Contribution des approches Temps- Fréquence à l'analyse des signaux et des images en génie biomédical, Innov. Technol. Biol. Med, vol.19, issue.3, 1998.

X. Zhang, L. G. Durand, L. Senhadji, H. C. Lee, and J. L. Coatrieux, Analysis-synthesis of the phonocardiogram based on the matching pursuit method, IEEE Transactions on Biomedical Engineering, vol.45, issue.8, pp.962-971, 1998.
DOI : 10.1109/10.704865

URL : https://hal.archives-ouvertes.fr/inserm-00460389

X. Zhang, L. G. Durand, L. Senhadji, C. Lee, and J. L. Coatrieux, Time-frequency scaling transformation of the phonocardiogram based of the matching pursuit method, IEEE Transactions on Biomedical Engineering, vol.45, issue.8, pp.972-979, 1998.
DOI : 10.1109/10.704866

URL : https://hal.archives-ouvertes.fr/inserm-00460388

L. Senhadji, J. J. Bellanger, G. M. Carrault, and . Ed, EEG spike detectors based on different decompositions: A comparative study, Time Frequency and Wavelets in Biomedical Engineering, pp.407-421, 1998.
URL : https://hal.archives-ouvertes.fr/inserm-00131461

F. Wendling, M. B. Shamsollahi, J. M. Badier, and J. J. Bellanger, Time-frequency matching of warped depth-EEG seizure observations, IEEE Transactions on Biomedical Engineering, vol.46, issue.5, pp.601-605, 1999.
DOI : 10.1109/10.759060

A. Hernandez, G. Carrault, F. Mora, and A. Bardou, Overview of Carmen: a new dynamic quantitative cardiac model for ECG monitoring and its adaptation to observed signals, Acta Biotheoretica, vol.48, issue.3/4, pp.303-322, 2000.
DOI : 10.1023/A:1010285632119

F. Wendling, J. J. Bellanger, F. Bartholomei, and P. Chauvel, Relevance of nonlinear lumped-parameter models in the analysis of depth-EEG epileptic signals, Biological Cybernetics, vol.83, issue.4, pp.367-378, 2000.
DOI : 10.1007/s004220000160

G. Friedland and B. Thurber, The birth of CT., American Journal of Roentgenology, vol.167, issue.6, pp.1365-1370, 1996.
DOI : 10.2214/ajr.167.6.8956560

P. Shrimpton and B. Wall, CT ??? an increasingly important slice of the medical exposure of patients, The British Journal of Radiology, vol.66, issue.791, pp.1067-1068, 1993.
DOI : 10.1259/0007-1285-66-791-1067

S. Webb, A review of physical aspects of X-ray transmission computed tomography, IEE Proceedings A Physical Science, Measurement and Instrumentation, Management and Education, Reviews, vol.134, issue.2, pp.126-135, 1987.
DOI : 10.1049/ip-a-1.1987.0019

R. Zeman, S. Fox, and P. Silverman, Helical (spiral) CT of the abdomen., American Journal of Roentgenology, vol.160, issue.4, pp.719-725, 1993.
DOI : 10.2214/ajr.160.4.8456652

R. Brooks, A Quantitative Theory of the Hounsfield Unit and Its Application to Dual Energy Scanning, Journal of Computer Assisted Tomography, vol.1, issue.4, pp.487-493, 1977.
DOI : 10.1097/00004728-197710000-00016

E. Crawley, characterization using quantitative computed tomography: a review, Journal of Medical Engineering & Technology, vol.9, issue.5, pp.233-242, 1990.
DOI : 10.3109/03091909009015430

W. Bautz, M. Strotzer, and M. Lenz, Spiral CT in the Preoperative Evaluation of Vessels of the Upper Abdomen, Radiology, vol.181, p.261, 1991.
DOI : 10.1007/978-3-642-77463-8_18

W. Kalender, R. Rienmüller, and . Seisslerw, Measurement of pulmonary parenchymal attenuation: use of spirometric gating with quantitative CT., Radiology, vol.175, issue.1, pp.265-268, 1990.
DOI : 10.1148/radiology.175.1.2315492

G. Rubin, C. Beaulieu, and V. Argiro, Perspective volume rendering of CT and MR images: applications for endoscopic imaging., Radiology, vol.199, issue.2, pp.321-330, 1996.
DOI : 10.1148/radiology.199.2.8668772

S. Fox, L. Tanenbaum, and S. Ackelsberg, Future directions in CT technology, Neuroimaging Clinics of North America, vol.8, pp.497-513, 1998.

W. Kalender, Quo vadis CT? CT in the year 2000, ELECTROMEDICA, vol.61, pp.30-39, 1993.

@. Références-additionnelles and W. A. Kalender, Computed Tomography: Fundamentals, System Technology, Image Quality, 2000.

@. Seeram and E. , Computed Tomography : Physical Principles, Clinical Applications and Quality Control, Pub. W.B. Saunders, 2001.

@. Bibliographie and B. S. Garnero-l, « A Bayesian framework to introducing anatomo-functional priors in the EEG/MEG inverse problem, IEEE Trans. Biomed. Eng, vol.44, pp.374-385

G. P. Sirigu-a and D. J. Scheinder-f, « Cortical reorganization in motor cortex after graft of both hands, Nature Neuroscience, vol.4, pp.691-692

M. S. Garnero-l, D. A. Mazières-l, L. S. Tezenas-du-montcel, and R. B. Vidailhet-m, « Human brain mapping in dystonia reveals both endophenotype traits and adaptative reorganization, Annals of Neurology, vol.50, pp.521-527

G. J. Molginer-a and R. U. , Somatosensory cortical plasticity in adult humans revealed by magnetoencephalography, pp.3593-3597

S. M. Von and C. D. , Evoked dipole source potentials of the human auditory cortex, Electroenceph. Clin. Neurophysiol, vol.65, pp.344-360

F. H. , E. T. Knecht-s, W. C. Pantev-c, and L. W. Birbaumer-n, « Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation, Nature, vol.375, pp.482-484

M. Cenci, Opinion: Animal models of neurological deficits: how relevant is the rat?, Nature Reviews Neuroscience, vol.3, issue.7, pp.574-583, 2002.
DOI : 10.1038/nrn877

J. Arbeit and R. Hirose, Murine Mentors: Transgenic and Knockout Models of Surgical Disease, Annals of Surgery, vol.229, issue.1, pp.21-40, 1999.
DOI : 10.1097/00000658-199901000-00004

M. Bader, Transgenic Animal Models for Neuropharmacology, Reviews in the Neurosciences, vol.11, issue.1, pp.27-36, 2000.
DOI : 10.1515/REVNEURO.2000.11.1.27

W. Russel and R. Burch, The Principles of Humane Experimental Technique, 1959.

R. and N. Magazine-de-la-recherche-européenne, Une science sans cobaye ? Novembre The Whole Frog Project, pp.26-27, 1994.

S. Hume, Pharmacological constraints associated with positron emission tomographic scanning of small laboratory animals, European Journal of Nuclear Medicine and Molecular Imaging, vol.25, issue.2, pp.173-179, 1998.
DOI : 10.1007/s002590050211

M. Paulus and M. Paulus, A new X-ray computed tomography system for laboratory mouse imaging, IEEE Transactions on Nuclear Science, vol.46, issue.3, pp.558-564, 1999.
DOI : 10.1109/23.775579

F. Foster, Ultrasound for the visualization and quantification of tumor microcirculation, Cancer and Metastasis Reviews, vol.19, issue.1/2, pp.131-139, 2000.
DOI : 10.1023/A:1026541510549

D. Turnbull, Ultrasound backscatter microscope analysis of early mouse embryonic brain development., Proceedings of the National Academy of Sciences, vol.92, issue.6, pp.2239-2282, 1995.
DOI : 10.1073/pnas.92.6.2239

S. Srinivasan, Noninvasive, In Utero Imaging of Mouse Embryonic Heart Development With 40-MHz Echocardiography, Circulation, vol.98, issue.9, pp.912-920, 1998.
DOI : 10.1161/01.CIR.98.9.912

J. Ruff, Magnetic resonance microimaging for noninvasive quantification of myocardial function and mass in the mouse, Magnetic Resonance in Medicine, vol.10, issue.1, pp.43-51, 1998.
DOI : 10.1002/mrm.1910400106

P. Scotland, in Premyelinated Axons, The Journal of Cell Biology, vol.30, issue.5, pp.1305-1320, 1998.
DOI : 10.1002/(SICI)1097-4547(19970315)47:6<655::AID-JNR12>3.0.CO;2-U

R. Weissleder, In vivo magnetic resonance imaging of transgene expression, Nature Medicine, vol.6, issue.3, pp.351-356, 2000.
DOI : 10.1038/73219

R. Lecomte, Initial results from the Sherbrooke avalanche photodiode positron tomograph, IEEE Transactions on Nuclear Science, vol.43, issue.3, pp.1952-1957, 1996.
DOI : 10.1109/23.507252

A. Jeavons, A 3D HIDAC-PET camera with sub-millimetre resolution for imaging small animals, IEEE Transactions on Nuclear Science, vol.46, issue.3, pp.468-473, 1999.
DOI : 10.1109/23.775564

A. Valda-ochoa, An original emission tomograph for in vivo brain imaging of small animals, IEEE Trans Nucl Sci, vol.44, issue.4, pp.1533-1537, 1997.
URL : https://hal.archives-ouvertes.fr/in2p3-00000629

A. Chatziioannou, Molecular imaging of small animals with dedicated PET tomographs, European Journal of Nuclear Medicine and Molecular Imaging, vol.29, issue.1, pp.98-114, 2002.
DOI : 10.1007/s00259-001-0683-3

R. Weissleder, Scaling down imaging : molecular mapping of cancer in mice Rapid and quantitative assessment of cancer treatment response using in vivo bioluminescence imaging, Nature Reviews Neoplasia, issue.2 26, pp.491-496, 2000.

W. Zhang, Rapid in vivo functional analysis of transgenes in mice using whole body imaging of luciferase expression, Transgenic Research, vol.10, issue.5, pp.423-457, 2001.
DOI : 10.1023/A:1012042506002

F. S. Foster, C. J. Pavlin, K. A. Harasiewicz, D. A. Christopher, and D. H. Turnbull, Advances in ultrasound biomicroscopy, Ultrasound in Medicine & Biology, vol.26, issue.1, pp.1-27, 2000.
DOI : 10.1016/S0301-5629(99)00096-4

M. Berson, J. M. Grégoire, F. Gens, J. Rateau, F. Jamet et al., High frequency (20 MHz) ultrasonic devices: advantages and applications, European Journal of Ultrasound, vol.10, issue.1, pp.53-63, 1999.
DOI : 10.1016/S0929-8266(99)00043-9

C. J. Pavlin and F. S. Foster, Ultrasound biomicroscopy of the eye, 1995.
DOI : 10.1007/978-1-4612-2470-9

M. Fink, Time reversal of ultrasonic fields. I. Basic principles, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, vol.39, issue.5, pp.555-566, 1992.
DOI : 10.1109/58.156174

F. Wu, J. Thomas, and M. Fink, Time reversal of utrasonics fields-Part II : experimental results, IEEE Ultrason Ferroelec Freq Contr, vol.39, pp.566-578, 1992.

D. Cassereau and M. Fink, Time reversal of utrasonics fields-Part III : theory of the closed time-reversal cavity, IEEE Ultrason Ferroelec Freq Contr, vol.39, pp.555-566, 1992.

M. Fink, Time-reversed acoustics » Scientific American, pp.67-73, 1999.
DOI : 10.1038/scientificamerican1199-91

M. Tanter, J. Thomas, and M. Fink, Time reversal and the inverse filter, The Journal of the Acoustical Society of America, vol.108, issue.1, pp.223-234, 2000.
DOI : 10.1121/1.429459

URL : https://hal.archives-ouvertes.fr/hal-00113152

J. Aubry, M. Tanter, J. Gerber, J. Thomas, and M. Fink, Optimal focusing by spatio-temporal inverse filter. I, J Acoust Soc Am, vol.110, pp.37-47, 2001.

J. Aubry, M. Tanter, J. Gerber, J. Thomas, and M. Fink, Optimal focusing by spatio-temporal inverse filter. II. Experiments. Application to focusing through absorbing and reverberating media, The Journal of the Acoustical Society of America, vol.110, issue.1, pp.48-58, 2001.
DOI : 10.1121/1.1377052

A. P. Sarvazyan, A. R. Skovoroda, S. Y. Emelianov, J. B. Fowlkes, J. G. Pipe et al., Biophysical Bases of Elasticity Imaging, Acoustical Imaging, pp.223-240, 1995.
DOI : 10.1007/978-1-4615-1943-0_23

L. Sandrin, S. Cathelin, M. Tanter, X. Hennequin, and M. Fink, Time-Resolved Pulsed Elastography with Ultrafast Ultrasonic Imaging, Ultrasonic Imaging, vol.21, issue.4, pp.259-272, 1999.
DOI : 10.1177/016173469902100402

L. Sandrin, M. Tanter, S. Catheline, and M. Fink, Shear modulus imaging with 2-D transient elastography, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, vol.49, issue.4, pp.426-435, 2002.
DOI : 10.1109/58.996560

L. Sandrin, M. Tanter, J. Gennisson, S. Catheline, and M. Fink, Shear elasticity probe for soft tissues with 1-D transient elastography, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, vol.49, issue.4, pp.436-446, 2002.
DOI : 10.1109/58.996561

C. Roux, B. Fournier, P. Laugier, C. Chappard, S. Kolta et al., Broadband ultrasound attenuation imaging: A new imaging method in osteoporosis, Journal of Bone and Mineral Research, vol.301, issue.8, pp.1112-1118, 1996.
DOI : 10.1002/jbmr.5650110810

S. Chaffaî, F. Peyrin, S. Nuzzo, R. Porcher, G. Berger et al., Ultrasonic characterization of human cancellous bone using transmission and backscatter measurements: relationships to density and microstructure, Bone, vol.30, issue.1, pp.229-237, 2002.
DOI : 10.1016/S8756-3282(01)00650-0

E. Camus, M. Talmant, G. Berger, and P. Laugier, Analysis of the axial transmission technique for the assessment of skeletal status, The Journal of the Acoustical Society of America, vol.108, issue.6, pp.3058-3065, 2000.
DOI : 10.1121/1.1290245

E. Bossy, M. Talmant, and P. Laugier, 2D Simulation of the Axial Transmission Technique on a Cortical Bone Plate, J Acoust Soc Am, vol.112, pp.297-307, 2002.
DOI : 10.1007/978-1-4419-8606-1_9

K. Svoboda, C. F. Schmidt, B. J. Schnapp, and S. M. Block, Direct observation of kinesin stepping by optical trapping interferometry, Nature, vol.365, issue.6448, pp.721-727, 1993.
DOI : 10.1038/365721a0

J. T. Finer, R. M. Simmons, and J. A. Spudich, Single myosin molecule mechanics: piconewton forces and nanometre steps, Nature, vol.311, issue.6467, pp.113-119, 1994.
DOI : 10.1038/368113a0

H. Noji, R. Yasuda, M. Yoshida, and K. Kinosita, Direct observation of the rotation of F1-ATPase, Nature, vol.386, issue.6622, pp.299-302, 1997.
DOI : 10.1038/386299a0

M. S. Kellermayer, S. B. Smith, H. L. Granzier, and C. Bustamante, Folding-Unfolding Transitions in Single Titin Molecules Characterized with Laser Tweezers, Science, vol.276, issue.5315, pp.1112-1116, 1997.
DOI : 10.1126/science.276.5315.1112

E. L. Florin, V. T. Moy, and H. E. Gaub, Adhesion forces between individual ligand-receptor pairs, Science, vol.264, issue.5157, pp.415-417, 1994.
DOI : 10.1126/science.8153628

M. Rief, M. Gautel, F. Oesterhelt, J. M. Fernandez, and H. E. Gaub, Reversible Unfolding of Individual Titin Immunoglobulin Domains by AFM, Science, vol.276, issue.5315, pp.1109-1112, 1997.
DOI : 10.1126/science.276.5315.1109

B. Essevaz-roulet, U. Bockelmann, and F. Heslot, Mechanical separation of the complementary strands of DNA, Proc. Nat. Acad. Sci, pp.11935-11940, 1994.
DOI : 10.1103/PhysRevLett.74.4754

B. Maier, T. Strick, J. Allemand, C. Gosse, D. Bensimon et al., Micromanipulation de molécules uniques d'ADN et de protéines, Energie et interface Physique Biologie ». Comptes rendus des Journées X-ENS/UPS de physique du 4 et 5 mai, 2000.

J. D. Watson and F. H. Crick, MOLECULAR STRUCTURE OF NUCLEIC ACIDS, JAMA, vol.269, issue.15, pp.737-738, 1953.
DOI : 10.1001/jama.1993.03500150078030

A. Einstein, Investigation of the Brownian theory of mouvement, 1956.

C. Bustamante, J. F. Marko, E. D. Siggia, and S. Smith, Entropic elasticity of lambda-phage DNA, Science, vol.265, issue.5178, pp.1599-1600, 1994.
DOI : 10.1126/science.8079175

J. F. Marko and E. D. Siggia, Fluctuations and supercoiling of DNA, Science, vol.265, issue.5171, pp.506-508, 1994.
DOI : 10.1126/science.8036491

C. Bouchiat, M. D. Wang, S. M. Block, J. Allemand, and V. Croquette, Estimating the Persistence Length of a Worm-Like Chain Molecule from Force-Extension Measurements, Biophysical Journal, vol.76, issue.1, pp.409-413, 1999.
DOI : 10.1016/S0006-3495(99)77207-3

J. H. White, Self-Linking and the Gauss Integral in Higher Dimensions, American Journal of Mathematics, vol.91, issue.3, pp.693-728, 1969.
DOI : 10.2307/2373348

J. F. Marko and E. Siggia, Statistical mechanics of supercoiled DNA, Physical Review E, vol.52, issue.3, pp.2912-2938, 1995.
DOI : 10.1103/PhysRevE.52.2912

C. Bouchiat and M. Mézard, Elasticity Model of a Supercoiled DNA Molecule, Physical Review Letters, vol.80, issue.7, pp.1556-1559, 1998.
DOI : 10.1103/PhysRevLett.80.1556

J. D. Moroz and P. Nelson, Torsional directed walks, entropic elasticity, and DNA twist stiffness, Proc. Nat. Acad. Sci, pp.14418-14422, 1997.
DOI : 10.1006/jmbi.1995.0640

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC25005

T. Strick, J. F. Allemand, D. Bensimon, A. Bensimon, and V. Croquette, The Elasticity of a Single Supercoiled DNA Molecule, Science, vol.271, issue.5257, pp.1835-1837, 1996.
DOI : 10.1126/science.271.5257.1835

T. Strick, J. Allemand, D. Bensimon, and V. Croquette, Behavior of Supercoiled DNA, Biophysical Journal, vol.74, issue.4, pp.2016-2028, 1998.
DOI : 10.1016/S0006-3495(98)77908-1

T. Strick, V. Croquette, and D. Bensimon, Homologous pairing in streched supercoiled DNA, Proc. Nat. Acad. Sci. (USA), pp.10579-10583, 1998.

T. Strick, D. Bensimon, and V. Croquette, Micro-mechanical measurement of the torsional modulus of DNA. Genetica, proceedings of NATO ARW on, Structural Biology and Functional Genomics, vol.106, pp.57-62, 1998.

B. Maier, D. Bensimon, and V. Croquette, Replication by a single DNA polymerase of a stretched single strand DNA, 2000.

T. Dna-polymerase-activity-wuite, G. J. Smith, S. Keller, D. Bustamante, and C. , Single-molecule studies of the effect of template tension on, Nature, vol.404, pp.103-106, 2000.

T. M. Lhoman and K. P. Bjornson, Mechanisms of Helicase-Catalyzed DNA Unwinding, Annual Review of Biochemistry, vol.65, issue.1, pp.169-214, 1996.
DOI : 10.1146/annurev.bi.65.070196.001125

J. C. Wang, Interaction between DNA and an Escherichia coli protein ??, Journal of Molecular Biology, vol.55, issue.3, pp.523-533, 1971.
DOI : 10.1016/0022-2836(71)90334-2

I. Single-molecule-analysis-of-topoisomerase, T. R. Strick, V. Croquette, and D. Bensimon, Preferential relaxation of positively supercoiled DNA by Escherichia coli topoisomerase IV in single molecule and ensemble measurements, Nature Genes and Development, vol.404, issue.14, pp.901-904, 2000.

N. H. Dekker, V. V. Rybenkov, M. Duguet, N. J. Crisona, N. R. Cozzarelli et al., The mechanism of type IA topoisomerases, Proceedings of the National Academy of Sciences, vol.95, issue.14, 2002.
DOI : 10.1073/pnas.95.14.7876

J. Castro, D. Linstadt, J. Bahary, P. Petti, I. Daftari et al., Experience in charged particle irradiation of tumors of the skull base: 1977???1992, International Journal of Radiation Oncology*Biology*Physics, vol.29, issue.4, pp.647-55, 1994.
DOI : 10.1016/0360-3016(94)90550-9

H. Tsujii, Current status of hadrontherapy with carbon ion beams, European Journal of Cancer, vol.37, issue.6, p.251, 2001.
DOI : 10.1016/S0959-8049(01)81420-9

J. Debus, T. Haberer, D. Schulz-ertner, O. Jakel, F. Wenz et al., Bestrahlung von Sch??delbasistumoren mit Kohlenstoffionen bei der GSI Erste klinische Ergebnisse und zuk??nftige Perspektiven, Strahlentherapie und Onkologie, vol.176, issue.5, pp.211-217, 2000.
DOI : 10.1007/s000660050002

D. Schulz-ertner, T. Haberer, O. Jakel, C. Thilmann, M. Kramer et al., Radiotherapy for chordomas and low-grade chondrosarcomas of the skull base with carbon ions, International Journal of Radiation Oncology*Biology*Physics, vol.53, issue.1, pp.36-42, 2002.
DOI : 10.1016/S0360-3016(01)02827-9

J. Gueulette, Proton RBE for early intestinal tolerance in mice after fractionated irradiation, Radiotherapy and Oncology, vol.61, issue.2, pp.61-177, 2001.
DOI : 10.1016/S0167-8140(01)00446-7

E. Projet, rapport LYCEN 2002-01 ou rapport DAPNIA ? 02-06 Résumé du projet Volume I : Aspects médicaux et économiques Avant-projet technique Disponibles en anglais et en français, Recherches associées, vol.II

D. Böhne, Synchrotrons for cancer therapy, EPAC, 1992.

U. Amaldi, A hospital based hadrontherapy complex, EPAC, 1994.

P. Mandrillon, High energy medical accelerators, EPAC, 1990.

P. Bryant, Developments in the design of proton and ion accelerators, 1998.

B. Kastler, Comprendre l'IRM, 2001.

D. Sappey-marinier and D. L. , Arnold : L'avenir de la résonance magnétique nucléaire en neurologie, La Lettre du Neurologue, 2001.

J. Maublant, J. Vuillez, and J. Talbot, Tomographie par émission de positons (TEP) et [F-18]-fluorodésoxyglucose (FDG) en cancérologie, Bull. Cancer, vol.85, p.935, 1998.