associations between a familial history of specific types of cancer in first and second degree relatives and childhood acute leukemia
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associations between a familial history of specific types of cancer in first and second degree relatives and childhood acute leukemia
| ALb | ALLc | AMLd | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| ICD- 9a | Controls n = 567 | n = 472 | ORe | 95%CIf | n = 407 | ORe | 95%CIf | n = 62 | ORe | 95%CIf | |
| Lip, oral cavity | 140–149 | 5 | 12 | 2.8 | (0.9–8.0) | 12 | 3.5 | (1.2–10) | 0 | - | |
| Esophagus, stomach | 150–152 | 7 | 11 | 1.8 | (0.9–1.6) | 10 | 1.9 | (0.7–5.1) | 1 | 1.3 | (0.1–11) |
| Colon, rectum | 153–154 | 10 | 12 | 1.5 | (0.6–3.4) | 8 | 1.1 | (0.4–2.9) | 4 | 3.9 | (1.1–13) |
| Liver, gallbladder | 155–157 | 11 | 13 | 1.2 | (0.5–2.8) | 12 | 1.4 | (0.6–3.2) | 1 | 0.5 | (0.1–4.2) |
| Lung | 162 | 17 | 17 | 1.2 | (0.6–2.4) | 15 | 1.3 | (0.6–2.7) | 2 | 0.9 | (0.2–4.1) |
| Melanoma | 172 | 2 | 6 | 4.4 | (0.8– 22) | 4 | 3.5 | (0.6–19) | 2 | 9.0 | (0.6– 19) |
| Breast | 174 | 34 | 30 | 1.1 | (0.6–1.8) | 27 | 1.1 | (0.6–1.9) | 3 | 0.7 | (0.2–2.6) |
| Uterus, ovary | 179–184 | 10 | 23 | 2.7 | (1.2–5.8) | 18 | 2.4 | (1.1–5.4) | 5 | 4.2 | (1.3–14) |
| Prostate | 185 | 5 | 3 | 0.7 | (0.1–3.2) | 2 | 0.5 | (0.1–2.9) | 1 | 2.7 | (0.3–27) |
| Kidney, bladder | 188–189 | 4 | 4 | 1.0 | (0.2–4.1) | 4 | 1.2 | (0.3–4.9) | 0 | - | |
| Thyroid | 193 | 2 | 4 | 2.6 | (0.4–15) | 4 | 3.3 | (0.6–19) | 0 | - | |
| Brain | 191 | 1 | 9 | 10.7 | (1.3–86) | 8 | 11.5 | (1.3–91) | 1 | 8.6 | (0.5–140) |
| Hematopoietic malignancy | 200–208 | 14 | 18 | 1.6 | (0.8–3.4) | 13 | 1.4 | (0.6–2.9) | 5 | 4.3 | (1.4–13) |
| Others sites | 48 | 46 | 1.1 | (0.7–1.7) | 40 | 1.1 | (0.7–1.7) | 6 | 1.3 | (0.5–3.0) | |