Logo of halHAL - Archives Ouvertes - Home page.

Table 4.

Familial history of solid tumor or hematopoietic malignancy by type of childhood acute leukemia

ALLa AMLb
Controls n = 567 (%) n = 407 (%) ORc 95% CId n = 62 (%) ORc 95% CId
History of cancer
 First-degree relative
  No 561 (99) 392 (96) 1.0 reference 58 (94) 1.0 reference
  Yes 6 (1) 15 (4) 3.6 [1.4–12] 4 (6) 4.7 [1.2–18]
 Second-degree relative
  No 424 (75) 266 (66) 1.0 reference 38 (61) 1.0 reference
  Yes 143 (25) 141 (34) 1.5 [1.1–2.0] 24 (39) 1.6 [0.9–2.8]
 First- or second-degree relative
  No 420 (74) 259 (64) 1.0 reference 36 (58) 1.0 reference
  Yes 147 (26) 148 (36) 1.6 [1.0–3.0] 26 (42) 1.7 [1.0–30]
History of solid tumor
 First-degree relative
  No 562 (99) 392 (97) 1.0 reference 59 (95) 1.0 reference
  Yes 5 (1) 14 (3) 4.5 [1.5–12] 3 (5) 4.5 [1.0–20]
 Second-degree relative
  No 432 (76) 275 (54) 1.0 reference 42 (68) 1.0 reference
  Yes 134 (24) 131 (46) 1.5 [1.1–2.0] 20 (32) 1.4 [0.8–2.5]
 First- or second-degree relative
  No 429 (76) 267 (66) 1.0 reference 40 (65) 1.0 reference
  Yes 137 (24) 139 (34) 1.6 [1.2–2.1] 22 (35) 1.6 [0.9–2.0]
History of hematopoietic malignancy
 First-degree relative
  No 548 (99.5) 382 (99) 1.0 reference 60 (98) 1.0 reference
  Yes 1 (0.5) 1 (1) 1.2 [0.1–20] 1 (2) 6.4 [0.4–113]
 Second-degree relative
  No 553 (98) 394 (97) 1.0 reference 58 (94) 1.0 reference
  Yes 13 (2) 12 (3) 1.4 [0.6–3.1] 4 (6) 3.8 [1.2–13]
 First- or second-degree relative
  No 552 (97) 393 (97) 1.0 reference 57 (92) 1.0 reference
  Yes 14 (3) 13 (3) 1.4 0.6–2.91 5 (8) 4.3 1.4–131
a ALL: Acute Lymphoblastic Leukemia.
b AML: Acute Myeloblastic Leukemia.
c OR: Odds ratios adjusted for age, gender, region of residence and family size.
d 95% CI: 95% confidence interval
Eur J Cancer Prev. 2007 October; 16(5): 466–70.
doi: 10.1097/01.cej.0000243849.82232.cb.