Development of new biocompatible 3D printed graphene oxide-based scaffolds - Laboratoire de Mécanique et Génie Civil Accéder directement au contenu
Article Dans Une Revue Materials Science and Engineering: C Année : 2020

Development of new biocompatible 3D printed graphene oxide-based scaffolds

Résumé

The aim of this work was to develop a bioresorbable, biodegradable and biocompatible synthetic polymer with good mechanical properties for bone tissue engineering applications. Polylactic acid (PLA) scaffolds were generated by 3D printing using the fused deposition modelling method, and reinforced by incorporation of graphene oxide (GO). Morphological analysis by scanning electron microscopy indicated that the scaffold average pore size was between 400 and 500 μm. Topography imaging revealed a rougher surface upon GO incorporation (Sa = 5.8 μm for PLA scaffolds, and of 9.9 μm for PLA scaffolds with 0.2% GO), and contact angle measurements showed a transition from a hydrophobic surface (pure PLA scaffolds) to a hydrophilic surface after GO incorporation. PLA thermomechanical properties were enhanced by GO incorporation, as shown by the 70 °C increase of the degradation peak (thermal gravimetric analysis). However, GO incorporation did not change significantly the melting point assessed by differential scanning calorimetry. Physicochemical analyses by X-ray diffraction and Raman spectroscopy confirmed the filler presence. Tensile testing demonstrated that the mechanical properties were improved upon GO incorporation (30% increase of the Young's modulus with 0.3% GO). Cell viability, attachment, proliferation and differentiation assays using MG-63 osteosarcoma cells showed that PLA/GO scaffolds were biocompatible and that they promoted cell proliferation and mineralization more efficiently than pure PLA scaffolds. In conclusion, this new 3D printed nanocomposite is a promising scaffold with adequate mechanical properties and cytocompatibility which may allow bone formation.
Fichier principal
Vignette du fichier
Art_Huon_al_Mat.-Sci.Eng._2020.pdf (1.91 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-02477859 , version 1 (13-02-2020)

Identifiants

Citer

Habib Belaïd, Sakthivel Nagarajan, Catherine Teyssier, Carole Barou, Jonathan Barés, et al.. Development of new biocompatible 3D printed graphene oxide-based scaffolds. Materials Science and Engineering: C, 2020, 110, pp.110595. ⟨10.1016/j.msec.2019.110595⟩. ⟨hal-02477859⟩
220 Consultations
489 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More