Rupture limit evaluation of human cerebral aneurysms wall: Experimental study

Hervé Brunel (1, 2) , Dominique Ambard (1, 3) , H Dufour (2) , P.H. Roche (2) , Vincent Costalat (4) , Franck Jourdan (1, 3)

1 LMGC - Laboratoire de Mécanique et Génie Civil
2 CHU Marseille
3 BIOTIC - Biomécanique des Interactions et de l'Organisation des Tissus et des Cellules
4 CHU Montpellier

BACKGROUND AND PURPOSE: Rupture risk of intracranial aneurysms is a major issue for public healthcare. A way to obtain an individual rupture risk assessment is a main objective of many research teams in the world. For many years, we have investigated the relationship between the mechanical properties of aneurysm wall tissues and the rupture risk. In this work, we try to go further and investigate rupture limit values. METHODS: Following surgical clipping, a specific conservation protocol was applied to aneurysmal tissues in order to preserve their mechanical properties. Thirty-nine intracranial aneurysms (27 females, 12 males) were tested using a uniaxial tensile test machine under physiological conditions, temperature, and saline isotonic solution. These represented 24 unruptured and 15 ruptured aneurysms. Stress/strain curves were then obtained for each sample, and a fitting algorithm was applied following a Yeoh hyperelastic model with 2 parameters. Moreover, uniaxial tensile tests were conducted until rupture of samples to obtain values of stress and strain rupture limit. RESULTS: The significant parameter a C2 of the hyperelastic Yeoh model, allowed us to classify samples' rigidity following the terminology we adopted in previous papers (Costalat et al., 2011; Sanchez et al., 2013): Soft, Stiff and Intermediate. Moreover, strain/stress rupture limit values were gathered and analyzed thanks to the tissue rigidity, the status of the aneurysm (initially ruptured or unruptured) and the gender of the patient. CONCLUSION: Strain rupture limit was found quite stable around 20% and seems not to be correlated with the status of the aneurysm (initially ruptured or unruptured), neither with the gender of the patient. However, stretch and stress rupture limit seems not to be independent on the rigidity. The study confirms that ruptured aneurysms mainly present a soft tissue and unruptured aneurysms present a stiff material.

Mots clés: Intracranial aneurysm; Soft tissue; Hyperelastic material; Rupture limit; human specimen; Uniaxial traction test

Domaines: Biomécanique [physics.med-ph]

Hervé Brunel, Dominique Ambard, H Dufour, P.H. Roche, Vincent Costalat, et al.. Rupture limit evaluation of human cerebral aneurysms wall: Experimental study. Journal of Biomechanics, 2018, 77, pp.76-82. ⟨10.1016/j.jbiomech.2018.06.016⟩. ⟨hal-01863317⟩