Uncommon Chlorinated Xanthone and Other Antibacterial Compounds from the Lichen Cladonia incrassata

Abstract : Bioassay-guided fractionation of an extract of the lichen Cladonia incrassata against Staphylococcus aureus led to a novel compound, 1,5-dihydroxy-2,4,6-trichloro-7-methylxanthone (1), along with six known compounds: (−)-usnic acid (2), didymic acid (3), condidymic acid (4), squamatic acid (5), thamnolic acid (6), and prasinic acid (7). Didymic, condidymic, and prasinic acids were isolated for the first time from C. incrassata. Didymic, condidymic, and (−)-usnic acids were active against S. aureus (a minimum inhibitory concentration of 7.5 µg/mL).
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https://hal-unilim.archives-ouvertes.fr/hal-01058414
Contributeur : Vincent Sol <>
Soumis le : mardi 26 août 2014 - 17:35:18
Dernière modification le : mardi 20 mars 2018 - 16:36:12

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Amandine Dieu, Marion Millot, Yves Champavier, Lengo Mambu, Vincent Chaleix, et al.. Uncommon Chlorinated Xanthone and Other Antibacterial Compounds from the Lichen Cladonia incrassata. Planta Medica, Georg Thieme Verlag, 2014, 80, pp.931-935. ⟨10.1055/s-0034-1382827⟩. ⟨hal-01058414⟩

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